Track 2: Comparison of Two Long-acting Injectables in Non-Human Primates with Magnetic Resonance Imaging

Long-acting injectable (LAI) formulations are designed to maintain prolonged drug exposure while reducing dosing frequency, however little is known about the tissue response over time. Magnetic resonance imaging (MRI) was utilized as a non-invasive method to monitor injection depot formation, volume changes, matrix degradation, and tissue response over time. Two vehicles were evaluated for continuous delivery of a small molecule compound in non-human primates: a conventional polyethylene glycol 300 (PEG300) based formulation and a poly (lactic-co-glycolic) acid in situ gel (PLGA-ISG). The objective was to characterize depot degradation and to provide in vivo insight into the mechanism of prolonged drug release observed with ISG formulations

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